"Folks with high blood pressure have to be careful with some medications," sais Dr. Diana Vinh, WVU School of Pharmacy. "Pain medications such as Ibuprofen can affect the blood pressure and raise the blood pressure in those folks."

Another over-the-counter medication for pain is acetaminophen; commonly known as Tylenol. Taken correctly, it's safe and entirely appropriate. But you need to watch out if you're taking a prescription that also contains acetaminophen.

Too much Tylenol can extensively damage your liver. So, be very careful if you're taking pain medication by prescription, that you don't double dip and take extra acetaminophen when you choose over-the-counter products.

"When it comes to natural supplements, natural does not always mean safe," said Dr. Kathy Moffett, WVU School of Medicine. "They can and do interact with prescription drugs. Even something as simple as a daily calcium tablet can make antibiotics less effective."

Your best source of information is your pharmacist. Tell him or her exactly which prescriptions, supplements and over-the-counter medications you take to avoid negative consequences.