The blaze broke out at about 10:17 a.m. at the 64000 block of Rock Hollow Road.
According to Belmont County dispatch the fire had been fully involved when crews arrived on scene.
Firefighters from Neffs, Bellaire and Cumberland Trial fire departments responded to the scene.
Dispatch said there have been no reported injuries and crews are uncertain if anyone was home when the blaze broke out.
Crews remain on scene and continue to fight the blaze.
The cause of the fire is unknown at this time pending investigation.
Stay with 7News and WTRF.com for updates on this developing story.