Madonna quarterback Ross Comis scored two touchdowns to lead the Blue Dons to a 49-12 victory at Clarksburg Notre Dame.
Comis carried the ball 12 times for 92 yards, and scored on runs of 17 and 9 yards.
Junior running back Elliott Nero added 108 yards on the ground, plus scored a defensive touchdown on an 86-yard interception return.
Junior running back Nick Ossman tacked on 104 yards rushing.
The No.8 Blue Dons, now 6-1, face a tough road test next Saturday with a trip to Harding Stadium to face Steubenville Catholic Central (6-2).