Wheeling Central scored five times in the bottom of the second inning to take control of their sectional game with Madonna.
The Knights went onto win 6-4.
Central now has control of the region one section one tournament, needing just one more win to advance to the regional.
Madonna and Bishop Donahue will meet Wednesday in an elimination game at Ed Bowman Field.
Nate Bakaitis and Derek Yocke each had two RBI for Central.