Martins Ferry trailed Wickliffe 13-7 at the half, but rallied in the second half for a 36-26 win and a 2-0 start.
Marcus Sutton scored twice to give the Riders a 22-19 lead after the third quarter.
In the fourth, Bruce Burger and Bryce Coleman as the Riders took a 36-19 lead.
The Riders will host 2-0 Linsly next week.
Jack Fitch had started the Ferry scoring in the first half with a 90 yard interception for a touchdown.