Madonna rolled to a 48-6 win over Cameron to improve to 4-0 on the season.
Senior quarterback Ross Comis carried the ball 11 times for 76 yards and three touchdowns. He also completed 9 of 15 passes for 179 yards and two more scores.
Elliott Nero rushed for 169 yards on 11 carries and a touchdown.
The Blue Dons are now 4-0 and host Bridgeport, while 1-4 Cameron will host Paden City.