Officials tell 7News that Route 250 in Harrison County is shutdown due to a motorcycle accident.
It happened approximately 5 miles east of Cadiz near Georgetown.
The driver and passenger were both flown by medical helicopter after overturning their bike after the accident on Three Bend Hill.
The 65 year old male driver was flown to Wheeling Hospital and the female passenger was flown to UPMC.
The seriousness of their injuries are not currently known.
Stay with 7News for the latest details on this developing story.